The management of the levodopa psychoses

Clin Neuropharmacol. 1991 Aug;14(4):283-95. doi: 10.1097/00002826-199108000-00001.


Parkinson's disease (PD) is frequently associated with psychiatric problems. Depression generally responds to antidepressant medications or to electroconvulsive therapy (ECT). The nondepressive psychoses generally require a reduction in parkinsonian medications, or possibly a "drug holiday." In patients whose psychosis fails to respond to a reduction in medication or who cannot tolerate the worsening parkinsonism, an antipsychotic drug should be added. Clozapine is probably the drug of choice, with low potency neuroleptics being second-line options.

Publication types

  • Review

MeSH terms

  • Antipsychotic Agents / therapeutic use
  • Electroconvulsive Therapy
  • Humans
  • Levodopa / adverse effects*
  • Psychoses, Substance-Induced / etiology
  • Psychoses, Substance-Induced / therapy*


  • Antipsychotic Agents
  • Levodopa