Cellular responses to DNA damage: one signal, multiple choices

Annu Rev Genet. 2006;40:187-208. doi: 10.1146/annurev.genet.40.110405.090428.


DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Cycle Proteins / metabolism
  • DNA Breaks, Double-Stranded
  • DNA Damage*
  • DNA Repair
  • DNA-Binding Proteins / metabolism
  • Genes, cdc / physiology
  • Humans
  • Signal Transduction*
  • Telomere / metabolism


  • Cell Cycle Proteins
  • DNA-Binding Proteins