Peroxisome Proliferator-Activated Receptor Alpha-Independent Peroxisome Proliferation

Biochem Biophys Res Commun. 2006 Aug 11;346(4):1307-11. doi: 10.1016/j.bbrc.2006.06.042. Epub 2006 Jun 16.

Abstract

Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor alpha (PPARalpha) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPARalpha-independent peroxisome proliferation, fenofibrate treatment was used, which was expected to significantly enhance PPARalpha dependence in the assay system. Surprisingly, a novel type of PPARalpha-independent peroxisome proliferation and enlargement was uncovered in PPARalpha-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11alpha, might be associated with the PPARalpha-independent peroxisome proliferation at least in part.

MeSH terms

  • Acyl-CoA Oxidase / metabolism
  • Animals
  • Fenofibrate / pharmacology
  • Hypolipidemic Agents / pharmacology
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Mice
  • PPAR alpha / physiology*
  • Peroxisome Proliferators
  • Peroxisomes / drug effects
  • Peroxisomes / physiology*
  • RNA, Messenger / metabolism

Substances

  • Hypolipidemic Agents
  • Membrane Proteins
  • PPAR alpha
  • Peroxisome Proliferators
  • Pex11alpha protein, mouse
  • RNA, Messenger
  • Acyl-CoA Oxidase
  • Fenofibrate