Collagenous pouchitis

Dig Liver Dis. 2006 Sep;38(9):704-9. doi: 10.1016/j.dld.2006.05.022. Epub 2006 Jun 27.


Collagenous colitis is characterised by watery diarrhoea, normal colonic mucosa on endoscopy, diffuse colitis with surface epithelial injury, and a distinctive thickening of the subepithelial collagen table on histology. Some patients can develop medically refractory collagenous colitis, in which case they may require surgical intervention. This is the first report of collagenous pouchitis in a collagenous colitis patient with proctocolectomy and ileal pouch-anal anastomosis. A patient with medically refractory collagenous colitis who underwent a total proctocolectomy and ileal pouch-anal anastomosis was sequentially evaluated with an endoscopy and histology of the colon, distal small intestine, and ileal pouch. A 58-year-old female had a 10-year history of collagenous colitis before having a total proctocolectomy and ileal pouch-anal anastomosis for medically refractory disease. The histologic features of collagenous colitis were present in all colon and rectum biopsy or resection specimens, but were absent in the distal ileum specimen. The post-operative course was complicated by persistent increase of stool frequency, abdominal cramps, and incontinence. A pouch endoscopy was performed 3 years after ileal pouch-anal anastomosis which showed the histologic features of collagenous colitis in the ileal pouch, collagenous pouchitis, while the pre-pouch neo-terminal ileum had no pathologic changes. After antibiotic therapy, the histologic changes of collagenous pouchitis resolved. This is the first reported case of collagenous pouchitis. Since the abnormal collagen table and its associated features were only present in the pouch and absent in the neo-terminal ileum, and the patient had histologic improvement after antibiotic therapy, it would suggest that faecal stasis and bacterial load may play a role in the pathogenesis.

Publication types

  • Case Reports

MeSH terms

  • Anal Canal / surgery
  • Anastomosis, Surgical
  • Anti-Bacterial Agents / therapeutic use
  • Ciprofloxacin / therapeutic use
  • Colitis, Collagenous / diagnosis*
  • Colitis, Collagenous / therapy
  • Endoscopy, Gastrointestinal
  • Female
  • Humans
  • Ileum / surgery
  • Middle Aged
  • Pouchitis / diagnosis*
  • Pouchitis / drug therapy
  • Proctocolectomy, Restorative
  • Tinidazole / therapeutic use


  • Anti-Bacterial Agents
  • Tinidazole
  • Ciprofloxacin