Many Roads Lead to "Auxin": Of Nitrilases, Synthases, and Amidases

Plant Biol (Stuttg). 2006 May;8(3):326-33. doi: 10.1055/s-2006-924075.


Recent progress in understanding the biosynthesis of the auxin, indole-3-acetic acid (IAA) in Arabidopsis thaliana is reviewed. The current situation is characterized by considerable progress in identifying, at the molecular level and in functional terms, individual reactions of several possible pathways. It is still too early to piece together a complete picture, but it becomes obvious that A. thaliana has multiple pathways of IAA biosynthesis, not all of which may operate at the same time and some only in particular physiological situations. There is growing evidence for the presence of an indoleacetamide pathway to IAA in A. thaliana, hitherto known only from certain plant-associated bacteria, among them the phytopathogen Agrobacterium tumefaciens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amidohydrolases / physiology
  • Aminohydrolases / physiology
  • Arabidopsis / enzymology
  • Arabidopsis / metabolism*
  • Indoleacetic Acids / metabolism*
  • Indoles / metabolism
  • Multienzyme Complexes / physiology
  • Oximes / metabolism
  • Plant Growth Regulators / metabolism*
  • Tryptamines / metabolism


  • Indoleacetic Acids
  • Indoles
  • Multienzyme Complexes
  • Oximes
  • Plant Growth Regulators
  • Tryptamines
  • indole-3-acetaldoxime
  • indole-3-acetic acid synthase
  • indol-3-yl pyruvic acid
  • indoleacetic acid
  • indoleacetamide
  • Amidohydrolases
  • Aminohydrolases
  • nitrilase