Incidence of and factors associated with achieving target lipid levels in patients with peripheral arterial disease

J Gen Intern Med. 2006 Jul;21(7):711-4. doi: 10.1111/j.1525-1497.2006.00456.x.


Background: Patients with peripheral arterial disease (PAD) have increased mortality compared with patients without PAD. Coronary artery disease (CAD) accounts for almost 75% of deaths in PAD patients. Studies suggest that PAD is underdiagnosed and atherosclerotic risk factors undertreated when compared with CAD.

Objective: To determine whether cholesterol guidelines are being met in patients with PAD and to determine whether any independent factors increase the likelihood of reaching goal low-density lipoprotein (LDL).

Design: A retrospective chart review of subjects diagnosed with PAD in 2001 at 2 Veterans Affairs Medical Centers.

Measurements: Univariate analysis compares baseline characteristics between those reaching goal and those who do not. Multivariate logistic regression analysis identified predictors of meeting LDL goal among PAD patients.

Results: Of 315 patients, 62% reached goal LDL. Those more likely to reach goal were older, had hypertension, and a history of CAD and stroke. Positive predictors of LDL goal were age and CAD, while smoking was a negative predictor.

Conclusion: The majority of veterans with PAD received lipid-lowering medication and achieve goal LDL, but they are more likely to do so if they are older than 70 and have a history of CAD.

MeSH terms

  • Aged
  • Analysis of Variance
  • Arterial Occlusive Diseases / blood*
  • Cholesterol, LDL / blood*
  • Florida
  • Humans
  • Hypolipidemic Agents / therapeutic use
  • Lipids / blood*
  • Middle Aged
  • Multivariate Analysis
  • Patient Compliance*
  • Regression Analysis
  • Retrospective Studies
  • Treatment Outcome


  • Cholesterol, LDL
  • Hypolipidemic Agents
  • Lipids