Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease

FASEB J. 2006 Aug;20(10):1695-7. doi: 10.1096/fj.06-5864fje. Epub 2006 Jun 29.

Abstract

Exposure to pesticides has been suggested to increase the risk of Parkinson's disease (PD), but the mechanisms responsible for this association are not clear. Here, we report that perinatal exposure of mice during gestation and lactation to low levels of dieldrin (0.3, 1, or 3 mg/kg every 3 days) alters dopaminergic neurochemistry in their offspring and exacerbates MPTP toxicity. At 12 wk of age, protein and mRNA levels of the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) were increased by perinatal dieldrin exposure in a dose-related manner. We then administered MPTP (2 x 10 mg/kg s.c) at 12 wk of age and observed a greater reduction of striatal dopamine in dieldrin-exposed offspring, which was associated with a greater DAT:VMAT2 ratio. Additionally, dieldrin exposure during development potentiated the increase in GFAP and alpha-synuclein levels induced by MPTP, indicating increased neurotoxicity. In all cases there were greater effects observed in the male offspring than the female, similar to that observed in human cases of PD. These data suggest that developmental exposure to dieldrin leads to persistent alterations of the developing dopaminergic system and that these alterations induce a "silent" state of dopamine dysfunction, thereby rendering dopamine neurons more vulnerable later in life.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacology
  • Animals
  • Animals, Newborn
  • Dieldrin / administration & dosage
  • Dieldrin / pharmacology*
  • Disease Models, Animal
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins / analysis
  • Dopamine Plasma Membrane Transport Proteins / genetics
  • Drug Synergism
  • Female
  • Lactation
  • Male
  • Mice
  • Neurotoxicity Syndromes / etiology*
  • Parkinson Disease, Secondary / chemically induced*
  • Parkinson Disease, Secondary / etiology
  • Pesticides / pharmacology
  • Pregnancy
  • RNA, Messenger / analysis
  • Vesicular Monoamine Transport Proteins / analysis
  • Vesicular Monoamine Transport Proteins / genetics

Substances

  • Dopamine Plasma Membrane Transport Proteins
  • Pesticides
  • RNA, Messenger
  • Slc18a2 protein, mouse
  • Vesicular Monoamine Transport Proteins
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Dieldrin
  • Dopamine