Prognosis of lupus membranous nephropathy in children

Pediatr Nephrol. 2006 Aug;21(8):1113-6. doi: 10.1007/s00467-006-0129-z. Epub 2006 Jun 30.


The occurrence of membranous nephropathy in pediatric series of systemic lupus erythematosus has been reported only rarely, probably due to a very low frequency. One hundred fifty-four children who were seen in 100 French pediatric centers between January 2002 and April 2005 were included. Fifteen (12 girls and three boys) out of the 81 (18.5 %) children with renal involvement presented histological features of membranous nephropathy. Their ages ranged from six to 15 years old (mean=11.3) at the age of SLE diagnosis and 8/15 children were of African origin. Isolated membranous nephropathy was observed in nine patients, of whom five patients displayed a complete recovery following immunosuppressive treatment. Associated proliferative lesions were observed on the first kidney specimen in two patients and in a further renal biopsy in four other patients, leading to a less favorable course of lupus nephropathy.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Child
  • Female
  • Glomerulonephritis, Membranous / drug therapy*
  • Glomerulonephritis, Membranous / etiology*
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Male
  • Prognosis