Perinatal stroke in twins without co-twin demise

Pediatr Neurol. 2006 Jul;35(1):75-7. doi: 10.1016/j.pediatrneurol.2005.12.008.


Perinatal stroke in twins without co-twin demise has not been well-described. In this study, the International Classification of Diseases- 9th edition code searches and medical record review were used to identify all children with arterial ischemic stroke examined in a pediatric stroke clinic over a 2-year period. Four of the 35 children (11.4%) with perinatal arterial ischemic stroke were twins; none had co-twin demise. No co-twin had any clinical evidence of perinatal stroke. The most common findings on prothrombotic evaluation were elevated antiphospholipid antibodies (2), elevated lipoprotein a (2), and elevated Factor VIIIc (2). Twin gestation without co-twin demise may be a risk factor for perinatal stroke, and might help explain the higher incidence of cerebral palsy in twins.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Child, Preschool
  • Diseases in Twins / diagnosis
  • Diseases in Twins / epidemiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Male
  • Stroke / diagnosis
  • Stroke / epidemiology*