Abstract
The antitussive activity of Crocus sativus stigma and petal extracts and its components, safranal and crocin, was evaluated using the nebolized solution of citric acid 20% in guinea pigs. The extract and agents were injected intraperitoneally. The ethanolic extract of C. sativus (100-800 mg/kg) and safranal (0.25-0.75 ml/kg) reduced the number of cough. The ethanolic and aqueous extracts of petal and crocin did not show antitussive activity.
MeSH terms
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Animals
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Antitussive Agents / administration & dosage
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Antitussive Agents / pharmacology*
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Antitussive Agents / therapeutic use
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Carotenoids / administration & dosage
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Carotenoids / pharmacology
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Carotenoids / therapeutic use
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Citric Acid
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Cough / drug therapy
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Crocus*
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Cyclohexenes
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Female
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Flowers
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Guinea Pigs
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Injections, Intraperitoneal
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Male
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Terpenes / administration & dosage
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Terpenes / pharmacology
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Terpenes / therapeutic use
Substances
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Antitussive Agents
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Cyclohexenes
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Plant Extracts
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Terpenes
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Citric Acid
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Carotenoids
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safranal
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crocin