Promoter cleavage: a topoIIbeta and PARP-1 collaboration

Cell. 2006 Jun 30;125(7):1225-7. doi: 10.1016/j.cell.2006.06.016.

Abstract

Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIbeta and poly(ADP-ribose) polymerase.

Publication types

  • Comment

MeSH terms

  • DNA Topoisomerases, Type II / chemistry
  • DNA Topoisomerases, Type II / metabolism*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • Estradiol / pharmacology
  • Humans
  • Models, Biological
  • Multiprotein Complexes
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases / chemistry
  • Poly(ADP-ribose) Polymerases / metabolism*
  • Promoter Regions, Genetic*
  • Transcription, Genetic / drug effects
  • Trefoil Factor-1
  • Tumor Suppressor Proteins / genetics

Substances

  • DNA-Binding Proteins
  • Multiprotein Complexes
  • TFF1 protein, human
  • Trefoil Factor-1
  • Tumor Suppressor Proteins
  • Estradiol
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • DNA Topoisomerases, Type II