Gene amplification: yeast takes a turn

Cell. 2006 Jun 30;125(7):1237-40. doi: 10.1016/j.cell.2006.06.012.


The origins of gene amplifications in mammalian cells have been difficult to analyze because of secondary genome rearrangements. Recent studies in budding yeast, including in this issue of Cell, have provided new insights into the role of palindromic sequences in gene amplification.

Publication types

  • Comparative Study
  • Review
  • Comment

MeSH terms

  • Animals
  • Gene Amplification*
  • Gene Duplication
  • Mammals / genetics
  • Models, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Saccharomyces cerevisiae / genetics*
  • Translocation, Genetic