Adiponectin plays an important role in efficient energy usage under energy shortage

Biochim Biophys Acta. 2006 Jul;1761(7):709-16. doi: 10.1016/j.bbalip.2006.04.016. Epub 2006 May 23.

Abstract

Adiponectin is an adipose tissue-specific secretory protein known to be an insulin-sensitizing protein. In this study, we generated adiponectin sense and antisense transgenic (Tg) mice to investigate whether adiponectin plays a role in the regulation of energy homeostasis during the growth stage. Spontaneous motor activity of antisense Tg mice were markedly reduced during fasting, particularly in young female mice, compared with wild type (Wt) and sense Tg mice. Furthermore, both body weight and adipose tissue mass of the antisense female Tg mice drastically reduced during fasting. To examine the relationship between the collapse of abdominal white adipose tissue (WAT) and serum adiponectin level, we measured the expression of genes related to energy expenditure, such as uncoupling protein (UCP). Notably, the mRNA of UCP1 in the WAT of antisense Tg female mice was markedly less than that of Wt mice and the UCP1 mRNA was strongly increased during fasting. These findings suggest that the serum adiponectin is important to maintaining energy homeostasis under energy shortage conditions, such as over female pubertal development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / genetics
  • Adiponectin / metabolism*
  • Adipose Tissue / metabolism
  • Aging / physiology
  • Animals
  • Body Weight
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • DNA, Antisense
  • Energy Metabolism* / genetics
  • Fasting
  • Female
  • Gene Expression Regulation, Developmental
  • Ion Channels
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / metabolism
  • Mice
  • Mice, Transgenic
  • Mitochondrial Proteins / genetics
  • Mitochondrial Proteins / metabolism
  • Organ Specificity
  • Sex Factors
  • Uncoupling Protein 1
  • Uncoupling Protein 2

Substances

  • Adiponectin
  • Carrier Proteins
  • DNA, Antisense
  • Ion Channels
  • Membrane Proteins
  • Membrane Transport Proteins
  • Mitochondrial Proteins
  • Ucp1 protein, mouse
  • Uncoupling Protein 1
  • Uncoupling Protein 2