Effects of topical antiglaucoma application on conjunctival impression cytology specimens

Am J Ophthalmol. 2006 Jul;142(1):185-6. doi: 10.1016/j.ajo.2006.02.056.

Abstract

Purpose: To evaluate the changes in conjunctival impression cytology specimens from patients receiving various topical antiglaucoma medications.

Design: Cross-sectional comparative study.

Methods: Impression cytology specimens were obtained from the eyes taking no topical medication (n = 20) and from the eyes taking various antiglaucoma medications (timolol n = 34; latanoprost n = 40; dorzolamide n = 32; timolol + latanoprost n = 30; timolol + dorzolamide n = 34). Specimens were graded on a scale of zero to three according to Nelson's method.

Results: Cytology scores were significantly higher in the medication group than the control group. Mean cytology scores of the control, timolol, latanoprost, dorzolamide, timolol + latanoprost, and timolol + dorzolamide group were 0.20, 1.62, 2.00, 1.75, 2.13, and 2.44, respectively. Among the medication groups, cytology scores were significantly lower in the monotherapy group than the fixed-combination therapy group.

Conclusions: Various topical antiglaucoma medications induce a significant degree of squamous metaplasia. Conjunctival surface could be altered after the long-term use of antiglaucoma medication.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Antihypertensive Agents / administration & dosage*
  • Conjunctiva / drug effects*
  • Conjunctiva / pathology*
  • Cross-Sectional Studies
  • Drug Therapy, Combination
  • Epithelium / drug effects
  • Epithelium / parasitology
  • Glaucoma, Open-Angle / drug therapy*
  • Humans
  • Latanoprost
  • Metaplasia
  • Prostaglandins F, Synthetic / administration & dosage
  • Sulfonamides / administration & dosage
  • Thiophenes / administration & dosage
  • Timolol / administration & dosage

Substances

  • Antihypertensive Agents
  • Prostaglandins F, Synthetic
  • Sulfonamides
  • Thiophenes
  • Latanoprost
  • Timolol
  • dorzolamide