A new locus for synaptic plasticity in cerebellar circuits

Neuron. 2006 Jul 6;51(1):5-7. doi: 10.1016/j.neuron.2006.06.014.


Experimental and computational analyses of cerebellar function indicate that excitatory synapses onto deep nucleus neurons are likely to be a critical site of plasticity during motor learning. In this issue of Neuron, Pugh and Raman report that unconventional stimulus protocols can drive synaptic plasticity in the deep cerebellar nuclei.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review
  • Comment

MeSH terms

  • Animals
  • Cerebellar Nuclei / physiology*
  • Conditioning, Psychological / physiology
  • Humans
  • Learning / physiology*
  • Nerve Fibers / physiology
  • Neural Inhibition / physiology
  • Neural Pathways / physiology*
  • Neuronal Plasticity / physiology*
  • Neurons / physiology*
  • Synaptic Transmission / physiology