Anthelmintic activity of Swertia chirata against gastrointestinal nematodes of sheep

Fitoterapia. 2006 Sep;77(6):463-5. doi: 10.1016/j.fitote.2006.05.010. Epub 2006 May 24.

Abstract

This paper describes in vitro and in vivo anthelmintic activities of Swertia chirata. In vitro studies revealed that at 25 mg/ml (P>/=0.05) the crude aqueous (CAE) and methanolic extracts (CME) of S. chirata whole plant showed an anthelmintic effect on live Haemonchus contortus. Moreover, in the in vivo study, the whole plant of S. chirata administered as crude powder (CP), CAE and CME at the dose of 3 g/kg to sheep naturally infected with mixed species of gastrointestinal nematodes, showed a significant reduction in egg per gram of faeces.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Antinematodal Agents / administration & dosage
  • Antinematodal Agents / pharmacology*
  • Antinematodal Agents / therapeutic use
  • Feces / parasitology
  • Female
  • Intestinal Diseases, Parasitic / drug therapy
  • Intestinal Diseases, Parasitic / veterinary
  • Male
  • Nematoda / drug effects*
  • Nematode Infections / drug therapy
  • Nematode Infections / veterinary
  • Parasite Egg Count
  • Parasitic Sensitivity Tests
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Sheep
  • Sheep Diseases / drug therapy
  • Sheep Diseases / parasitology
  • Swertia*

Substances

  • Antinematodal Agents
  • Plant Extracts