Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Nat Med. 2006 Jul;12(7):790-2. doi: 10.1038/nm1436. Epub 2006 Jul 2.


In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / therapeutic use*
  • Cervix Uteri / physiopathology
  • Disease Models, Animal
  • Female
  • Macaca
  • Motor Activity / drug effects*
  • Myelin Proteins / immunology*
  • Nogo Proteins
  • Uterine Cervical Diseases / immunology*


  • Antibodies
  • Myelin Proteins
  • Nogo Proteins