Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis

J Med Food. 2006 Summer;9(2):290-2. doi: 10.1089/jmf.2006.9.290.


The antimicrobial effect of mastic gum, an ancient remedy for oral malodor, against Porphyromonas gingivalis, a known odorogenic periopathogenic oral bacterium, was tested using the agar diffusion test. Paper discs impregnated with mastic gum methanolic extract (MME) [0.5-4% (wt/vol)] produced inhibition zones of 10.5-13.7 mm, respectively, without showing signs of hemolysis, whereas chlorhexidine (0.2%)-impregnated discs, which showed greater inhibition (33.5 mm), also produced large and distinctive hemolytic zones (17 mm). Further analysis of the antimicrobial traits of MME revealed a logarithmic ratio between inhibition zone diameter and MME concentration (r = .99), indicating limited water solubility of this material. These results suggest that mastic gum may be used as a potential nontoxic local agent in treating oral malodor and gum disease.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Chlorhexidine / pharmacology
  • Mastic Resin
  • Methanol
  • Microbial Sensitivity Tests
  • Plant Extracts / pharmacology*
  • Porphyromonas gingivalis / drug effects*
  • Resins, Plant / chemistry*


  • Anti-Infective Agents
  • Mastic Resin
  • Plant Extracts
  • Resins, Plant
  • Chlorhexidine
  • Methanol