PARK8 LRRK2 parkinsonism

Curr Neurol Neurosci Rep. 2006 Jul;6(4):287-94. doi: 10.1007/s11910-006-0020-0.


Parkinson's disease (PD) is the most common form of parkinsonism, affecting nearly 2% of people older than 65 years of age. Symptomatic treatment has been available for decades, but to date there is no treatment retarding disease progression. Over the past decade several genes causing parkinsonism have been identified in families with a mendelian pattern of inheritance. The most recent is the leucine-rich repeat kinase 2 (LRRK2) gene. Pathogenic mutations in the LRRK2 gene cause a significant proportion of clinically typical, late-onset PD. This review summarizes the current knowledge on the contribution of LRRK2 mutations in understanding parkinsonism.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • DNA Mutational Analysis
  • Family Health
  • Female
  • Gene Frequency
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / genetics*
  • Pedigree
  • Positron-Emission Tomography
  • Protein-Serine-Threonine Kinases / genetics*


  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein-Serine-Threonine Kinases