Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 6 (4), 332-40

State of the Ketogenic Diet(s) in Epilepsy

Review

State of the Ketogenic Diet(s) in Epilepsy

Jennifer Huffman et al. Curr Neurol Neurosci Rep.

Abstract

Fasting has been recognized as a treatment for seizures since ancient times. The ketogenic diet is a low-carbohydrate, adequate-protein, high-fat diet that biochemically mimics the fasting state and has been used to successfully treat seizures for 85 years. The diet has enjoyed a resurgence in popularity over the past decade and is gaining acceptance and use worldwide. Many studies over the past several years have explored possible mechanisms of action for the ketogenic diet. This review addresses these studies, as well as recent research regarding possible indications for the diet, variations in its initiation, side effect profiles, and the recent use of modified formulations to improve tolerability.

Similar articles

  • Clinical Aspects of the Ketogenic Diet
    AL Hartman et al. Epilepsia 48 (1), 31-42. PMID 17241206. - Review
    The ketogenic diet remains a valuable therapeutic option for patients with intractable epilepsy. Clinical aspects of the diet's success may provide insights into epilepto …
  • [Dietary Aspects of Epilepsy]
    N Kozák et al. Ideggyogy Sz 60 (5-6), 234-8. PMID 17578270. - Review
    The ketogenic diet has been used long for the treatment of epilepsy. The high-fat, low-carbohydrate diet creates ketosis. Although the exact mechanism of action is unknow …
  • Anticonvulsant Mechanisms of the Ketogenic Diet
    KJ Bough et al. Epilepsia 48 (1), 43-58. PMID 17241207. - Review
    The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy. Despite nearly a century of use, the mechanisms underlying its clinical effica …
  • The Ketogenic Diet in Children With Epilepsy
    D Papandreou et al. Br J Nutr 95 (1), 5-13. PMID 16441911. - Review
    Children with epilepsy, especially those facing intractable seizures, experience a great impact on the quality of their lives. Effective treatment is essential, and altho …
  • [The Role of the Ketogenic Diet in the Management of Epilepsy]
    A Starbała et al. Rocz Panstw Zakl Hig 58 (1), 139-44. PMID 17711102. - Review
    Ketogenic Diet is effective in the treatment of epilepsy in both children and adults. KD increases the effectiveness of conventional therapies and can be applied for the …
See all similar articles

Cited by 9 PubMed Central articles

See all "Cited by" articles

References

    1. Pediatrics. 2002 May;109(5):780-3 - PubMed
    1. Epilepsia. 2005 Nov;46(11):1810-9 - PubMed
    1. Epilepsy Curr. 2004 Nov-Dec;4(6):215-22 - PubMed
    1. Pediatr Nephrol. 2000 Nov;15(1-2):125-8 - PubMed
    1. Neuroscience. 2003;120(2):365-78 - PubMed

MeSH terms

Feedback