Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jun 12;168(24):2354-61.

[Mutations in the Epidermal Growth Factor Receptor: Structure and Biological Function in Human Tumors]

[Article in Danish]
Affiliations
  • PMID: 16822420
Review

[Mutations in the Epidermal Growth Factor Receptor: Structure and Biological Function in Human Tumors]

[Article in Danish]
Mikkel Wandahl Pedersen et al. Ugeskr Laeger. .

Abstract

The epidermal growth factor receptor (EGFR) plays an important role in the regulation of normal cell proliferation, differentiation and survival. For this reason EGFR status is often altered in a range of human tumor types and generally correlates with a poor prognosis. In recent years a number of mutations in the EGFR gene have been noted that lead to the expression of overactive or constitutively active aberrant receptors. These receptors have been shown to participate actively in the process of tumor genesis. This review provides an overview of the structure of these mutations and their biological function in human tumors plus the potentials of anticancer therapy.

Similar articles

See all similar articles

Cited by 3 articles

Publication types

MeSH terms

LinkOut - more resources

Feedback