Metabolic cycles as an underlying basis of biological oscillations

Nat Rev Mol Cell Biol. 2006 Sep;7(9):696-701. doi: 10.1038/nrm1980. Epub 2006 Jul 5.


The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Circadian Rhythm / physiology*
  • Hibernation / physiology*
  • Humans
  • Saccharomyces cerevisiae / physiology*