AMP-activated protein kinase signaling in metabolic regulation

J Clin Invest. 2006 Jul;116(7):1776-83. doi: 10.1172/JCI29044.


AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and lipid oxidation to produce energy, while turning off energy-consuming processes including glucose and lipid production to restore energy balance. AMPK controls whole-body glucose homeostasis by regulating metabolism in multiple peripheral tissues, such as skeletal muscle, liver, adipose tissues, and pancreatic beta cells--key tissues in the pathogenesis of type 2 diabetes. By responding to diverse hormonal signals including leptin and adiponectin, AMPK serves as an intertissue signal integrator among peripheral tissues, as well as the hypothalamus, in the control of whole-body energy balance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases
  • Energy Metabolism*
  • Glucose / metabolism
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / metabolism*
  • Muscle, Skeletal / metabolism
  • Protein Serine-Threonine Kinases / chemistry
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction / physiology*


  • Isoenzymes
  • Multienzyme Complexes
  • Protein Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Glucose