Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer

Annu Rev Cell Dev Biol. 2006;22:287-309. doi: 10.1146/annurev.cellbio.22.010305.104315.

Abstract

The microenvironment influences gene expression so that the behavior of a cell is largely determined by its interactions with the extracellular matrix, neighboring cells, and soluble local and systemic cues. We describe the essential roles of context and organ structure in directing mammary gland development and differentiated function and in determining the response to oncogenic insults, including mutations. We expand on the concept of "dynamic reciprocity" to present an integrated view of development, cancer, and aging and posit that genes are like the keys on a piano: Although they are essential, it is the context that makes the music.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Breast Neoplasms / pathology*
  • Extracellular Matrix / metabolism*
  • Homeostasis*
  • Humans
  • Mammary Glands, Human / cytology*
  • Organ Specificity
  • Signal Transduction*