Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine

Lancet. 1991 Nov 9;338(8776):1174-5. doi: 10.1016/0140-6736(91)92034-y.


2 patients had neurological symptoms and signs, with evidence of central-nervous-system demyelination, 6 weeks after administration of recombinant hepatitis B vaccine. 1 had known multiple sclerosis but the other had no history of neurological disease; both had HLA haplotypes DR2 and B7, which are associated with multiple sclerosis. A causal link between vaccination and demyelination cannot be established from these 2 case-reports, but the time interval would fit a proposed immunological mechanism.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Demyelinating Diseases / etiology*
  • Female
  • Hemiplegia / etiology*
  • Hepatitis B Vaccines
  • Humans
  • Multiple Sclerosis / complications
  • Vaccines, Synthetic / adverse effects*
  • Viral Hepatitis Vaccines / adverse effects*


  • Hepatitis B Vaccines
  • Vaccines, Synthetic
  • Viral Hepatitis Vaccines