Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma

Lancet. 1991 Nov 9;338(8776):1175-6. doi: 10.1016/0140-6736(91)92035-z.


Although lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in the stomach and most of these recapitulate the features of mucosa-associated lymphoid tissue (MALT). Gastric lymphoid tissue is known to be acquired in response to local infection by Helicobacter pylori, and we have confirmed this in 450 patients with H pylori-associated gastritis of whom 125 showed mucosal lymphoid follicles. In 8 patients, B lymphocytes infiltrated epithelium, which is a feature characteristic of MALT. We also examined 110 cases of gastric MALT lymphoma and found H pylori infection in 101 of these (92%). We conclude that gastric MALT is acquired in H pylori infection and that this provides the necessary background in which MALT lymphoma might develop.

MeSH terms

  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Gastritis / microbiology*
  • Gastritis / pathology
  • Helicobacter Infections* / pathology
  • Helicobacter pylori*
  • Humans
  • Lymphoma, B-Cell / microbiology*
  • Lymphoma, B-Cell / pathology
  • Retrospective Studies
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / pathology