Upper airway obstruction during nasal intermittent positive-pressure hyperventilation in sleep

Lancet. 1991 Nov 23;338(8778):1295-7. doi: 10.1016/0140-6736(91)92593-q.


Episodes of apnoea for up to 1 min were observed in association with hypocapnia caused by passive nasal intermittent positive-pressure mechanical hyperventilation in 3 of 4 patients during sleep. Apnoea seemed to be caused by complete upper airways obstruction; we suggest that this finding was caused by active glottic closure. Avoidance of excessive hypocapnia during positive-pressure ventilation might help to avoid central-nervous-system mediated apnoeic episodes.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Electroencephalography
  • Electromyography
  • Female
  • Glottis / physiopathology
  • Humans
  • Hypocapnia / etiology
  • Intermittent Positive-Pressure Ventilation / adverse effects*
  • Nasal Obstruction / complications*
  • Nasal Obstruction / physiopathology
  • Sleep Apnea Syndromes / etiology*
  • Sleep Apnea Syndromes / physiopathology