Beneficial effects of statins on perioperative cardiovascular outcome

Curr Opin Anaesthesiol. 2006 Aug;19(4):418-22. doi: 10.1097/


Purpose of review: This review evaluates clinical and experimental articles that have recently been published on the cardioprotective effect of perioperative statin therapy.

Recent findings: Perioperative statin therapy improves short and long-term cardiac outcome following noncardiac surgery. This cardiovascular protection has been attributed to the so-called pleiotropic effects, which have a positive effect on plaque stability. With no clinical studies reporting an increased incidence of adverse effects of perioperative statin use, it appears to be a safe and helpful therapeutic option.

Summary: Perioperative statin therapy may stabilize coronary plaques due to pleiotropic effects and results in a reduction of perioperative cardiovascular complications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atherosclerosis / complications
  • Atherosclerosis / prevention & control
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control*
  • Clinical Trials as Topic
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Myocardial Infarction / prevention & control
  • Perioperative Care*
  • Postoperative Complications / prevention & control*
  • Treatment Outcome


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors