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, 7 (7), 473-83

Reading Protein Modifications With Interaction Domains


Reading Protein Modifications With Interaction Domains

Bruce T Seet et al. Nat Rev Mol Cell Biol.


Proteins are controlled by a vast and dynamic array of post-translational modifications, many of which create binding sites for specific protein-interaction domains. We propose that these domains, working together, read the state of the proteome and therefore couple post-translational modifications to cellular organization. We also identify common strategies through which modification-dependent interactions synergize to regulate cell behaviour.

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