EGF-ERBB signalling: towards the systems level

Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16. doi: 10.1038/nrm1962.


Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis / physiology
  • Epidermal Growth Factor / metabolism*
  • ErbB Receptors / chemistry
  • ErbB Receptors / genetics
  • ErbB Receptors / metabolism
  • Feedback, Physiological
  • Humans
  • Ligands
  • Models, Molecular
  • Oncogene Proteins v-erbB / genetics
  • Oncogene Proteins v-erbB / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Protein Conformation
  • Signal Transduction / physiology*


  • Ligands
  • Oncogene Proteins v-erbB
  • Epidermal Growth Factor
  • Phosphatidylinositol 3-Kinases
  • ErbB Receptors