CHox E, a chicken homeogene of the H2.0 type exhibits dorso-ventral restriction in the proliferating region of the spinal cord

Mech Dev. 1991 Aug;35(1):13-24. doi: 10.1016/0925-4773(91)90037-7.


CHox E is a novel chicken homeogene that belongs to the H2.0 family of homeodomains. Its homeobox sequence is interrupted by an intron between amino acids 44 and 45. Expression of CHox E during embryogenesis is localized to the central nervous system. The anterior boundary of CHox E expression can initially be localized to rhombomere number 1, later in development this boundary reaches up to the rhombencephalic isthmus. CHox E expression in the spinal cord localizes dorso-ventrally to the dorsal half of the basal plate. CHox E expression is always restricted to the proliferating region, the ventricular zone. As the ventricular zone becomes restricted laterally, so does the CHox E expressing region. Once this region of the ventricular zone ceases to exist, CHox E specific transcripts become undetectable. The site and time of CHox E expression suggest a very early function in the differentiation of the cells derived from that region of the ventricular zone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Differentiation / physiology
  • Cell Division / physiology
  • Chick Embryo
  • DNA / genetics
  • Embryonic and Fetal Development / physiology
  • Gene Expression Regulation / physiology*
  • Genes, Homeobox / genetics
  • Genes, Homeobox / physiology*
  • Introns
  • Molecular Sequence Data
  • Neurons / cytology
  • Neurons / metabolism
  • Neurons / physiology
  • Spinal Cord / cytology
  • Spinal Cord / embryology
  • Spinal Cord / physiology*
  • Transcription, Genetic / genetics


  • DNA

Associated data

  • GENBANK/M81959
  • GENBANK/S66451
  • GENBANK/S66454
  • GENBANK/S78944
  • GENBANK/S78945
  • GENBANK/S78946
  • GENBANK/S78947
  • GENBANK/S78948
  • GENBANK/S78949
  • GENBANK/S78950
  • GENBANK/X59548
  • GENBANK/X59549