beta A4 amyloid protein deposition in brain after head trauma

Lancet. 1991 Dec 7;338(8780):1422-3. doi: 10.1016/0140-6736(91)92724-g.


Previous reports have suggested that both repetitive head trauma and a single injury can be associated with the presence of diffuse beta A4 amyloid protein plaques in long-term survivors. We have studied sixteen patients (aged 10-63 years) who sustained head injury and survived for only 6-18 days. Immunostaining with an antibody to beta A4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients (38%). Thus, severe head injury can trigger beta A4 deposition in the brain within days.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amyloid beta-Peptides / analysis*
  • Brain Chemistry*
  • Cerebral Cortex / chemistry
  • Child
  • Craniocerebral Trauma / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Time Factors


  • Amyloid beta-Peptides