Replicon Typing of Plasmids Encoding Resistance to Newer Beta-Lactams

Emerg Infect Dis. 2006 Jul;12(7):1145-8. doi: 10.3201/eid1207.051555.

Abstract

Polymerase chain reaction-based replicon typing represents a novel method to describe the dissemination and follow the evolution of resistance plasmids. We used this approach to study 26 epidemiologically unrelated Enterobacteriaceae and demonstrate the dominance of incompatibility (Inc) A/C or Inc N-related plasmids carrying some emerging resistance determinants to extended-spectrum cephalosporins and carbapenems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Enterobacter cloacae / drug effects
  • Enterobacter cloacae / genetics
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Klebsiella oxytoca / drug effects
  • Klebsiella oxytoca / genetics
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics
  • Plasmids / genetics*
  • Polymerase Chain Reaction
  • Replicon / genetics*
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Sensitivity and Specificity
  • beta-Lactam Resistance / genetics*
  • beta-Lactams / pharmacology*

Substances

  • Anti-Bacterial Agents
  • beta-Lactams