The role of CD44 adhesion molecule in oral cavity cancer

Exp Oncol. 2006 Jun;28(2):94-8.

Abstract

CD44 is an adhesion molecule, member of the transmembrane glucoprotein family, with large number of isoforms identified in many human tissues, with particularly high expression in proliferating cells and squamous cell epithelium. This review is focused on the role of CD44 in the carcinogenesis of the oral cavity with special emphasis on its potential use for diagnosis and prognosis of cancer of oral cavity.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Biomarkers, Tumor / metabolism
  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / etiology*
  • Carcinoma, Squamous Cell / metabolism
  • Humans
  • Hyaluronan Receptors / analysis*
  • Hyaluronan Receptors / metabolism
  • Hyaluronan Receptors / physiology*
  • Mouth Neoplasms / diagnosis*
  • Mouth Neoplasms / etiology*
  • Mouth Neoplasms / metabolism
  • Prognosis

Substances

  • Biomarkers, Tumor
  • Hyaluronan Receptors