Clarifying the mechanics of DNA strand exchange in meiotic recombination

Nature. 2006 Jul 13;442(7099):153-8. doi: 10.1038/nature04885.


During meiosis, accurate separation of maternal and paternal chromosomes requires that they first be connected to one another through homologous recombination. Meiotic recombination has many intriguing but poorly understood features that distinguish it from recombination in mitotically dividing cells, and several of these features depend on the meiosis-specific DNA strand exchange protein Dmc1 (disrupted meiotic cDNA1). Many questions about this protein have arisen since its discovery more than a decade ago, but recent genetic and biochemical breakthroughs promise to shed light on the unique behaviours and functions of this central player in the remarkable chromosome dynamics of meiosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Animals
  • Cell Cycle Proteins / metabolism
  • Crossing Over, Genetic / genetics
  • Crossing Over, Genetic / physiology*
  • DNA / genetics
  • DNA / metabolism*
  • DNA-Binding Proteins / metabolism
  • Humans
  • Meiosis / genetics*
  • Models, Genetic
  • Sequence Homology, Nucleic Acid


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • DNA
  • Adenosine Triphosphatases
  • DMC1 protein, human