Current dilemmas in Down syndrome clinical care: celiac disease, thyroid disorders, and atlanto-axial instability

Am J Med Genet C Semin Med Genet. 2006 Aug 15;142C(3):141-8. doi: 10.1002/ajmg.c.30102.


This study will discuss our current understanding of celiac disease (CD), thyroid disorders, and atlanto-axial instability, three important areas of medical management in individuals with Down syndrome (DS). In this study, we highlight our current knowledge, as well as what we need to study in order to gather the necessary data to refine the empirically based screening protocols which are now in place.

Publication types

  • Review

MeSH terms

  • Atlanto-Axial Joint
  • Celiac Disease / diagnosis
  • Celiac Disease / etiology*
  • Celiac Disease / therapy*
  • Child
  • Clinical Protocols
  • Down Syndrome / complications*
  • Down Syndrome / therapy*
  • Humans
  • Infant
  • Joint Instability / diagnosis
  • Joint Instability / etiology*
  • Joint Instability / therapy*
  • Thyroid Diseases / diagnosis
  • Thyroid Diseases / etiology*
  • Thyroid Diseases / therapy*