Regulation of Rho proteins by phosphorylation in the cardiovascular system

Trends Cardiovasc Med. 2006 Aug;16(6):199-204. doi: 10.1016/j.tcm.2006.03.010.


The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular functions, and activation of Rho proteins appears to be a common component for the pathogenesis of hypertension and vascular proliferative disorders. Rho proteins are tightly regulated, and recent evidence suggests that modulation of Rho protein signaling by phosphorylation of Rho proteins provides an additional simple mechanism for coordinating Rho protein functions. This regulation by phosphorylation is particularly important in the arterial wall, where RhoA protein expressed in vascular smooth muscle cells is controlled by the endothelium through the nitric oxide/cGMP-dependent kinase pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular System / metabolism*
  • Cardiovascular System / pathology
  • Cardiovascular System / physiopathology
  • Humans
  • Phosphorylation
  • Signal Transduction
  • rho GTP-Binding Proteins / classification
  • rho GTP-Binding Proteins / metabolism*
  • rho GTP-Binding Proteins / physiology


  • rho GTP-Binding Proteins