Flipping riboswitches

Cell. 2006 Jul 14;126(1):19-22. doi: 10.1016/j.cell.2006.06.024.


Riboswitches are common cis-acting regulatory elements in bacteria. They are made of nascent RNA that changes its conformation in response to direct binding of cognate metabolites. The publication of five high-resolution crystal structures provides a comprehensive view of how riboswitches sense their ligands and points to new challenges in this emerging field.

Publication types

  • Review

MeSH terms

  • Bacteria / genetics*
  • Binding Sites / genetics
  • Crystallography, X-Ray / trends
  • Gene Expression Regulation, Bacterial / genetics
  • Ligands
  • Models, Molecular
  • Molecular Biology / trends
  • Nucleic Acid Conformation
  • RNA, Bacterial / chemistry*
  • RNA, Bacterial / genetics*
  • Regulatory Elements, Transcriptional / genetics*


  • Ligands
  • RNA, Bacterial