Abstract
Pot1 is a conserved single-stranded DNA binding protein with crucial functions in the protection of telomeres and maintenance of their length. In this issue of Cell, two papers (Hockemeyer et al., 2006; Wu et al., 2006) examine the roles of murine Pot1 homologs and describe intriguing new insights into how cells protect their chromosome ends from DNA-repair activities.
MeSH terms
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Animals
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Cellular Senescence / genetics
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DNA / chemistry
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DNA / genetics*
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DNA Damage / genetics*
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DNA Repair / genetics*
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DNA-Binding Proteins / genetics*
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Gene Expression Regulation / genetics
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Mice
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Shelterin Complex
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Signal Transduction / genetics
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Telomere / genetics*
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Telomere-Binding Proteins
Substances
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DNA-Binding Proteins
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POT1 protein, mouse
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Shelterin Complex
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Telomere-Binding Proteins
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DNA