Are mouse telomeres going to pot?

Cell. 2006 Jul 14;126(1):33-6. doi: 10.1016/j.cell.2006.06.027.

Abstract

Pot1 is a conserved single-stranded DNA binding protein with crucial functions in the protection of telomeres and maintenance of their length. In this issue of Cell, two papers (Hockemeyer et al., 2006; Wu et al., 2006) examine the roles of murine Pot1 homologs and describe intriguing new insights into how cells protect their chromosome ends from DNA-repair activities.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cellular Senescence / genetics
  • DNA / chemistry
  • DNA / genetics*
  • DNA Damage / genetics*
  • DNA Repair / genetics*
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation / genetics
  • Mice
  • Signal Transduction / genetics
  • Telomere / genetics*

Substances

  • DNA-Binding Proteins
  • POT1 protein, mouse
  • DNA