Alternative splicing: new insights from global analyses

Cell. 2006 Jul 14;126(1):37-47. doi: 10.1016/j.cell.2006.06.023.


Recent analyses of sequence and microarray data have suggested that alternative splicing plays a major role in the generation of proteomic and functional diversity in metazoan organisms. Efforts are now being directed at establishing the full repertoire of functionally relevant transcript variants generated by alternative splicing, the specific roles of such variants in normal and disease physiology, and how alternative splicing is coordinated on a global level to achieve cell- and tissue-specific functions. Recent progress in these areas is summarized in this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Evolution, Molecular
  • Gene Expression Profiling / methods
  • Gene Expression Profiling / trends
  • Gene Expression Regulation / genetics*
  • Humans
  • Molecular Biology / methods*
  • Molecular Biology / trends*
  • Oligonucleotide Array Sequence Analysis / methods
  • Oligonucleotide Array Sequence Analysis / trends
  • Protein Isoforms / biosynthesis
  • Protein Isoforms / genetics
  • RNA, Messenger / biosynthesis*
  • RNA, Messenger / genetics*
  • Regulatory Elements, Transcriptional / genetics
  • Ribonucleoproteins, Small Nuclear / genetics


  • Protein Isoforms
  • RNA, Messenger
  • Ribonucleoproteins, Small Nuclear