Quantitative measurement of blood-brain barrier permeability using perfusion-CT in extra-axial brain tumors

J Neuroradiol. 2006 Jun;33(3):164-8. doi: 10.1016/s0150-9861(06)77254-6.


Non-invasive assessment of vascular permeability is of main importance in the diagnosis, treatment and follow-up of intracranial tumors. Perfusion-CT is one of the imaging options available, which affords quantitative assessment of cerebral blood volume and blood-brain barrier permeability. Herein we report two cases of extra-axial tumors studied with perfusion-CT. Comparison with perfusion-MRI was available in one case. High permeability values, as measured by perfusion-CT, reflected the absence of blood-brain barrier in these extra-axial tumors.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Blood-Brain Barrier*
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / secondary
  • Cerebrovascular Circulation
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Meningioma / diagnostic imaging*
  • Middle Aged
  • Permeability
  • Tomography, X-Ray Computed / methods*