Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas

Eur J Nucl Med. 1991;18(11):924-7. doi: 10.1007/BF02258458.


Tyr-3-Octreotide is a synthetic derivative of somatostatin and a somatostatin-receptor analogue. The iodine-123-labelled compound localizes somatostatin-receptor-positive tumours. In this paper two patients are reported in whom somatostatin receptors were demonstrated in vitro. In a 60-year-old female with an islet cell carcinoma of the pancreas, multiple liver metastases and previously unrecognized bone metastases in the right acetabulum could be diagnosed as the reason for a persistent hypoglycaemia. In a 60-year-old male an islet cell carcinoma of the pancreas was localized with 123I-Tyr-3-octreotide. The somatostatin receptors were demonstrated in vitro and the tumour was successfully treated with somatostatin. These studies demonstrate that 123I-Tyr-3-octreotide offers the possibility of localizing somatostatin-receptor-positive tumours and their metastases. Moreover the method makes it possible to determine the receptor status of a tumour in vivo.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Islet Cell / chemistry
  • Adenoma, Islet Cell / diagnostic imaging*
  • Adenoma, Islet Cell / secondary
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / secondary
  • Female
  • Humans
  • Iodine Radioisotopes
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged
  • Octreotide*
  • Pancreatic Neoplasms / chemistry
  • Pancreatic Neoplasms / diagnostic imaging*
  • Receptors, Neurotransmitter / analysis*
  • Receptors, Somatostatin
  • Somatostatin / analysis*
  • Tomography, Emission-Computed, Single-Photon


  • Iodine Radioisotopes
  • Receptors, Neurotransmitter
  • Receptors, Somatostatin
  • Somatostatin
  • Octreotide