Prognosis of decompensated heart failure patients with preserved systolic function is predicted by NT-proBNP variations during hospitalization

Int J Cardiol. 2007 Apr 12;117(1):75-9. doi: 10.1016/j.ijcard.2006.06.004. Epub 2006 Jul 14.


Background: Almost half of heart failure (HF) patients have preserved left ventricular systolic function (LVSF). Although morbidity is similar in patients with preserved and depressed LVSF, clinicians have limited information on prognostic factors of patients with preserved LVSF. We aimed to evaluate the prognostic value of NT-proBNP in patients with decompensated HF regardless of LVSF.

Methods: Patients hospitalised due to decompensated HF were followed for 6 months. The primary endpoint was death or hospital readmission. We evaluated 224 patients with NT-proBNP measured at admission and discharge and an echocardiogram performed. NT-proBNP decreased on average during hospitalization in patients with preserved LVSF (n=63) and in patients with depressed LVSF (n=161). The morbidity was not different between patients with preserved and depressed LVSF. Among patients with preserved LVSF, predictors of adverse events were serum creatinine, haemoglobin, NT-proBNP levels at discharge and the variation in NT-proBNP during hospitalisation. Among patients with depressed LVSF, predictors of adverse events were female gender, atrial fibrillation, non-prescription of ACE-inhibitor at discharge, NT-proBNP levels at discharge and the variation in NT-proBNP during hospitalisation.

Conclusions: These results suggest that, in HF patients with preserved LVSF as in patients with depressed LVSF, NT-proBNP can play a role as a tool to identify patients at risk of an adverse outcome.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Biomarkers / blood
  • Female
  • Follow-Up Studies
  • Heart Failure / blood*
  • Heart Failure / diagnosis*
  • Heart Failure / mortality
  • Heart Failure / physiopathology
  • Hospitalization / statistics & numerical data*
  • Humans
  • Male
  • Multivariate Analysis
  • Natriuretic Peptide, Brain / blood*
  • Patient Readmission / statistics & numerical data
  • Peptide Fragments / blood*
  • Portugal / epidemiology
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Regression Analysis
  • Survival Analysis
  • Systole
  • Ventricular Function


  • Biomarkers
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain