Serial NetEvolve: a flexible utility for generating serially-sampled sequences along a tree or recombinant network

Bioinformatics. 2006 Sep 15;22(18):2313-4. doi: 10.1093/bioinformatics/btl387. Epub 2006 Jul 14.


Serial NetEvolve is a flexible simulation program that generates DNA sequences evolved along a tree or recombinant network. It offers a user-friendly Windows graphical interface and a Windows or Linux simulator with a diverse selection of parameters to control the evolutionary model. Serial NetEvolve is a modification of the Treevolve program with the following additional features: simulation of serially-sampled data, the choice of either a clock-like or a variable rate model of sequence evolution, sampling from the internal nodes and the output of the randomly generated tree or network in our newly proposed NeTwick format.

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Supplementary information: Manual and examples available from

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms*
  • Computer Graphics
  • Computer Simulation
  • Evolution, Molecular
  • Models, Genetic*
  • Recombination, Genetic / genetics*
  • Sequence Analysis, DNA / methods*
  • Signal Transduction / genetics
  • Software*
  • User-Computer Interface*