Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W683-5. doi: 10.1093/nar/gkl299.


G-quadruplex secondary structures, which play a structural role in repetitive DNA such as telomeres, may also play a functional role at other genomic locations as targetable regulatory elements which control gene expression. The recent interest in application of quadruplexes in biological systems prompted us to develop a tool for the identification and analysis of quadruplex-forming nucleotide sequences especially in the RNA. Here we present Quadfinder, an online server for prediction and bioinformatics of uni-molecular quadruplex-forming nucleotide sequences. The server is designed to be user-friendly and needs minimal intervention by the user, while providing flexibility of defining the variants of the motif. The server is freely available at URL http://miracle.igib.res.in/quadfinder/.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • G-Quadruplexes
  • Guanine / chemistry*
  • Internet
  • RNA / chemistry
  • Sequence Analysis, DNA / methods*
  • Sequence Analysis, RNA / methods*
  • Software*
  • User-Computer Interface


  • Guanine
  • RNA
  • DNA