Dopaminergic neurons expressing calbindin in normal and parkinsonian monkeys

Neuroreport. 1991 Oct;2(10):601-4. doi: 10.1097/00001756-199110000-00012.


In cynomolgus monkeys, midbrain neurons immunoreactive (IR) for the calcium-binding protein calbindin D-28k (CaBP) occur principally in the dorsal tier of substantia nigra pars compacta (SNc) and in the ventral tegmental area (VTA), and most of these neurons co-express tyrosine hydroxylase (TH). In monkeys rendered parkinsonian (PD) after MPTP injections, CaBP-IR neurons are much less severely affected than TH-IR neurons in SNc and in VTA, and most spared neurons in SNc/VTA display both CaBP and TH immunoreactivity. These results reveal that, in contrast to the situation in other neurodegenerative diseases, CaBP may be used as a marker for a specific neuronal population that is less prone to degeneration in Parkinson's disease.

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Calbindins
  • Dopamine / metabolism*
  • Immunohistochemistry
  • Macaca fascicularis
  • Mesencephalon / cytology
  • Mesencephalon / metabolism*
  • Mesencephalon / pathology
  • Neurons / cytology
  • Neurons / metabolism*
  • Neurons / pathology
  • Organ Specificity
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / metabolism*
  • Parkinson Disease, Secondary / pathology
  • Reference Values
  • S100 Calcium Binding Protein G / analysis
  • S100 Calcium Binding Protein G / metabolism*
  • Tyrosine 3-Monooxygenase / analysis
  • Tyrosine 3-Monooxygenase / metabolism*


  • Calbindins
  • S100 Calcium Binding Protein G
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Tyrosine 3-Monooxygenase
  • Dopamine