Plenty new under the sun

J Invest Dermatol. 2006 Aug;126(8):1691-2. doi: 10.1038/sj.jid.5700345.


Variation at the melanocortin 1 receptor (MC1R) is very common in most non-African world populations. A range of variants predispose to skin cancer, including melanoma. What remains unclear are the mechanisms linking gene variation with sun sensitivity or tumor risk. In particular, it remains unclear whether pigmentary effects of the MC1R can account for all of the increase in cancer risk.

Publication types

  • Comment
  • Review

MeSH terms

  • Humans
  • Melanoma / epidemiology*
  • Melanoma / genetics*
  • Receptor, Melanocortin, Type 1 / genetics*
  • Risk Factors
  • Skin Neoplasms / epidemiology*
  • Skin Neoplasms / genetics*
  • Skin Pigmentation / genetics


  • Receptor, Melanocortin, Type 1