Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?

J Invest Dermatol. 2006 Aug;126(8):1693-6. doi: 10.1038/sj.jid.5700458.


Although BRAF V600 mutations in melanocytic tumors are not UV-signature mutations, it is plausible that they could still arise from error-prone replication of UV-damaged DNA. We propose a mechanism for their origin, taking into consideration melanocytic-specific BRAF tandem mutations, nearby potential pyrimidine dimer sites, the properties of specialized DNA polymerases, and biological selection.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • DNA Damage*
  • Humans
  • Melanoma / epidemiology
  • Melanoma / genetics*
  • Neoplasms, Radiation-Induced / epidemiology
  • Neoplasms, Radiation-Induced / genetics*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Risk Factors
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / genetics*
  • Ultraviolet Rays


  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf