Fibrosarcoma with typical features of postinjection sarcoma at site of microchip implant in a dog: histologic and immunohistochemical study

Vet Pathol. 2006 Jul;43(4):545-8. doi: 10.1354/vp.43-4-545.


A 9-year-old, male French Bulldog was examined for a subcutaneous mass located at the site of a microchip implant. Cytologic examination of the mass was suggestive of a malignant mesenchymal neoplasm. Histologically, the mass was confirmed as a high-grade infiltrative fibrosarcoma, with multifocal necrosis and peripheral lymphoid aggregates. By immunohistochemistry, the sample was investigated for vimentin, smooth-muscle actin (SMA), CD3, CD79alpha, and CD18. All the neoplastic cells were positive for vimentin. Scattered cells at the periphery of the lesion were also positive for SMA, highlighting a myofibroblastic phenotype. The lymphoid cells were positive for CD18 and CD3. No aluminum deposits were detected by the aurintricarboxylic acid method. A diagnosis of fibrosarcoma morphologically similar to feline postinjection sarcomas was made. Fibrosarcomas at the site of injections have been reported in dogs and ferrets. Furthermore, neoplastic growth at the site of microchip implant in dog and laboratory rodents has been described.

Publication types

  • Case Reports

MeSH terms

  • Animal Identification Systems* / veterinary
  • Animals
  • Dog Diseases / etiology
  • Dog Diseases / pathology*
  • Dog Diseases / surgery
  • Dogs
  • Fibrosarcoma / etiology
  • Fibrosarcoma / pathology
  • Fibrosarcoma / surgery
  • Fibrosarcoma / veterinary*
  • Head and Neck Neoplasms / etiology
  • Head and Neck Neoplasms / pathology
  • Head and Neck Neoplasms / surgery
  • Head and Neck Neoplasms / veterinary*
  • Immunohistochemistry / veterinary
  • Male
  • Prostheses and Implants / adverse effects*
  • Prostheses and Implants / veterinary*