Lasting neuropsychiatric sequelae of (+-)methylenedioxymethamphetamine ('ecstasy') in recreational users

J Clin Psychopharmacol. 1991 Oct;11(5):302-5.

Abstract

Two persons are described who demonstrated prolonged neuropsychiatric syndromes after the ingestion of large doses of (+-)-3,4-methylenedioxymethamphetamine (MDMA), a recreationally used amphetamine analog. These cases suggest that MDMA, known to be neurotoxic to serotonin neurons in several experimental animals, may also produce untoward effects in humans. In addition, they provide evidence that ingestion of large doses of MDMA can produce lasting adverse functional consequences in vulnerable persons.

Publication types

  • Case Reports

MeSH terms

  • 3,4-Methylenedioxyamphetamine / administration & dosage
  • 3,4-Methylenedioxyamphetamine / adverse effects
  • 3,4-Methylenedioxyamphetamine / analogs & derivatives*
  • Adolescent
  • Adult
  • Anxiety Disorders / chemically induced
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / psychology
  • Depressive Disorder / chemically induced
  • Depressive Disorder / diagnosis
  • Depressive Disorder / psychology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • N-Methyl-3,4-methylenedioxyamphetamine
  • Neuropsychological Tests / statistics & numerical data*
  • Psychometrics
  • Psychoses, Substance-Induced / diagnosis
  • Psychoses, Substance-Induced / psychology*
  • Substance-Related Disorders / complications
  • Substance-Related Disorders / psychology

Substances

  • 3,4-Methylenedioxyamphetamine
  • N-Methyl-3,4-methylenedioxyamphetamine